GLYCERYL TRINITRATE / NITROGLYCERIN / TRINITRIN |
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GLYCERYL TRINITRATE / NITROGLYCERIN / TRINITRIN
Prescription under medical supervision
Indications
– Vasodilator, antianginal
Dosage
– Short-term prophylaxis and treatment of angina
– 0.5 mg sublingual tablet
– Short-term prophylaxis of acute angina (sublingually)
Adult: 0.5 to 1 mg taken 5 to 10 minutes before a precipitating event (exercise, stress, etc.)
Duration: according to clinical response
– Treatment of acute angina (sublingually)
Adult: 0.5 to 1 mg, to be repeated 1 to 3 times at 3-4 minute intervals
Maximum dose: 3 mg/day
Contra-indications, adverse effects, precautions
– Do not administer to patients with obstructive cardiomyopathy, hypotension, shock.
– May cause: orthostatic hypotension (especially in elderly patients), headache, nausea,
flushing of the face, haemolysis in patients with G6PD deficiency, severe hypotension with
risk of circulatory collapse in the event of overdose.
– Use the lowest effective dose in patients taking another nitrate derivative, a vasodilator or an antihypertensive drug and in elderly patients.
– Combination with antihypertensive drugs, diuretics, vasodilators and alcohol enhances
hypotensive effects.
– Do not combine with sildenafil (risk of acute coronary syndrome).
– Pregnancy: not recommended (safety is not established)
– Breast-feeding: not recommended (safety is not established)
– Tablet must be crunched first, then slowly dissolved under the tongue.
– Antianginal effect appears within less than 5 minutes and persists for less than 1 hour.
– Sustained-release formulations (Sustac®, etc.) are used for the long-term management of
angina and the treatment of congestive heart failure.
–– Storage: below 25°C, preferably in airtight glass container.
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