GH hypersecretion occurring in adult life after epiphyseal closure results in acromegaly.
Soft tissue changes Thickening of skin, increased skin tags, acanthosis nigricans, increased sweat and sebum resulting
Bone changes - Large spade-like hands, large feet, prognathism, prominent supraorbital ridges, large frontal sinuses,
Investigations of pituitary tumour (refer pituitary tumour).
Primary treatment with drugs is indicated in:
Various drugs are:
Bromocriptine or cabergoline (dopamine agonist) are useful in those with mildly elevated IGF-I.